Research Article
Biphasic Regulation of Lipid Metabolism: A Meta-Analysis of Icodextrin in Peritoneal Dialysis
Table 3
Effect of icodextrin use on lipid profiles (RCT and cohort studies).
| Factor | Number of studies | Heterogeneity test | Weighted mean difference | | | value | Model of meta | Mean | [95% CI] | value |
| Total cholesterol (mmol/L) | 7 | 3.70 | 46.10% | 0.190 | F | | | <0.001 | Triglycerides (mmol/L) | 6 | 21.02 | 76.20% | 0.001 | R | | | 0.206 | HDL-C (mmol/L) | 4 | 7.41 | 59.50% | 0.06 | R | | | 0.245 | LDL-C (mmol/L) | 4 | 9.87 | 69.60% | 0.02 | R | | | 0.922 | VLDL-C (mmol/L) | 2 | 0.09 | <0.01% | 0.762 | F | | | 0.529 | Free fatty acid (mol/L) | 2 | 0.04 | <0.01% | 0.845 | F | | | 0.004 | Lipoprotein(a) (mg/dL) | 2 | 8.69 | 88.50% | 0.003 | R | | | 0.481 |
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Note: the value was less than 0.05, and the WMD was considered statistically significant. Model of meta: F: Fixed, R: Random.
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