Biphasic Regulation of Lipid Metabolism: A Meta-Analysis of Icodextrin in Peritoneal Dialysis

Table 5

Effect of icodextrin on lipid profiles (in subgroups of duration).

Factor	Duration	Number of studies	Heterogeneity test				Weighted mean difference
					value	Model of meta	Mean	[95% CI]	value
Total cholesterol (mmol/L)	<6 month	6	9.49	47.30%	0.091	F			0.096
	≥6 month	4	8.50	43.40%	0.112	F			<0.001
Triglycerides (mmol/L)	<6 month	5	26.45	84.90%	<0.001	R			0.096
	≥6 month	3	4.32	33.6%	0.213	F			0.004
HDL-C (mmol/L)	<6 month	4	1.19	<0.01%	0.754	F			0.760
	≥6 month	2	0.76	<0.01%	0.383	F			0.469
LDL-C (mmol/L)	<6 month	4	4.71	36.3%	0.194	F			0.435
	≥6 month	2	<0.01	<0.01%	0.982	F			0.495
VLDL-C (mmol/L)	<6 month	4	0.09	<0.01%	0.761	F			0.527
Free fatty acid (mol/l)	<6 month	2	1.13	11.50%	0.288	F			0.009

Note: the value was less than 0.05, and the WMD was considered statistically significant.
Model of meta: F: Fixed, R: Random.