Plasma Protein Biomarker Candidates for Myelodysplastic Syndrome Subgroups

Table 1

Patients’ characteristics.

Patient	Sex	Age	Diagnosis	Karyotype	WBC [10^9/L]	PLT [10^9/L]	Blasts in PB [%]	NS [%]	IPSS	IPSS-R
1	f	21	RCMD	46, XX	3.51	31	0	22.9	Good	Very good
2	f	24	RCMD	46, XX	4.79	238	0	52	Good	Very good
3	f	29	RCMD	46, XX	3.93	19	0	27	Good	Very good
4	m	29	RCMD	46, XY-polyploidy	3.81	50	0	73	Good	Very good
5	f	30	RCMD	46, XX	2.53	134	0	36	Good	Very good
6	m	30	RCMD	46, XY	7.96	107	0	69	Good	Very good
7	m	49	RAEB2	46, XY	4.34	15	3	23	Good	Very good
8	f	50	RA	46, XX	3.64	184	0	59	Good	Very good
9	f	50	RCMD	46, XX, inv(9)	1.81	108	0	48	Intermediate	Intermediate
10	f	51	RCMD	46, XX, 9qh+	3.80	20	0	58	Intermediate	Intermediate
11	m	55	RCMD	46, XY	2.19	236	0	25	Good	Very good
12	f	56	RCMD	46, XX	3.90	129	0	39	Good	Very good
13	f	56	RCMD	46, XX	4.15	211	0	71	Good	Very good
14	m	58	RAEB1	45, XY, −18, multiple aberrations	1.26	28	0	30	Poor	Very poor
15	f	58	RAEB2	42~47, XX, del(5)(q?), −7, +8, der(12)t(7; 12)(?; p?13)ins(12; 7)(q?12; ?)ins(12; 7)(q?13; ?), der(17)t(17; 20)(p11.2; ?)	1.57	310	5.2	43.2	Poor	Very poor
16	m	58	RCMD	46, XY −46, XY, del(20)(q12)	2.00	211	0	56	Good	Good
17	m	58	RCMD	46, XY	2.48	153	0	55	Good	Very good
18	m	59	RAEB2	46, XY −43~44, XY, multiple changes	2.30	110	14	18	Poor	Very poor
19	m	59	RCMD	46, XY	2.81	103	0	50	Good	Very good
20	f	60	RA	46, XX	7.41	149	0	60	Good	Very good
21	m	60	RAEB1	46, XY	0.65	88	0	34	Good	Very good
22	f	60	RAEB2	46, XX	5.36	39	11	46	Good	Very good
23	m	61	RARS	46, XY	5.84	218	0	67	Good	Very good
24	m	62	RCMD	46, XY −45, X, −Y	6.82	89	0	65	Good	Very good
25	f	62	RCMD	46, XX	2.58	28	0	51	Good	Very good
26	m	62	RCMD	46, XY	4.49	56	0	61	Good	Very good
27	f	63	RA	46, XX −46, XX, del(5)(q13q13)	3.54	146	0	52	Good	Good
28	f	64	RAEB1	46, XX, t(2; 12)(p22; q13)	5.91	121	1	44	Intermediate	Intermediate
29	f	65	RA	46, XX −46, XX, del(5)(q15q33)	3.20	192	1	29	Good	Good
30	m	65	RCMD	46, XY −43~46, XY, der(2)t(2; 12)(q37; ?), del(11)(q13)	2.93	297	0	43	Poor	Very poor
31	m	66	RCMD	46, XY, 21ps+	6.74	81	0	52	Intermediate	Intermediate
32	f	66	RCMD	46, XX	2.79	16	0	84.3	Good	Very good
33	f	67	RAEB2	—	3.93	22	14	28	—	—
34	f	68	RAEB1	46, XX −46, XX, del(5)(q22q33)	3.80	412	0	50	Good	Good
35	m	68	RCMD	46, XY −45, X, −Y	19.94	399	3	51	Good	Very good
36	f	70	RAEB1	46, XX	1.13	150	0	46	Good	Very good
37	m	70	RAEB2	5q31 deletion (8 of 11 tests)	3.70	156	8	73	Good	Good
38	m	71	RAEB1	46, XY	4.25	85	3	17	Good	Very good
39	m	71	RAEB1	46, XY	1.39	21	0	20	Good	Very good
40	f	72	RCMD	46, XX, del(5)(q13.3q33.3)	4.18	119	0	47	Good	Good
41	f	76	RAEB2	47–51, XX-multiple changes	1.52	8	2	42	Poor	Very poor
42	m	78	RA	46, XY	8.65	162	0	75	Good	Very good
43	f	78	RA	46, XX, del(5)(q13q33)	3.77	288	0	67	Good	Good
44	m	78	RA	46, XY	5.36	243	1	68	Good	Very good
45	f	79	RAEB2	46, XX -46, XX, del(5)(q13q33)	0.43	6	38	8	Good	Good
46	f	86	RARS	46, XX	8.86	375	0	55	Good	Very good
47	m	89	RARS	46, XY	6.44	155	0	40	Good	Very good

WBC: white blood cells; PLT: platelets; PB: peripheral blood; NS: neutrophil segments.