Comparative Genome and Network Centrality Analysis to Identify Drug Targets of Mycobacterium tuberculosis H37Rv

Table 2

Proteins in the top 20 of all of the four centrality measures.

Protein	Functional class	Network centrality scores				PDB
		Betweenness	Eigenvector	Degree	Closeness
Rv1303	Cell wall and cell processes	115190.99	0.1066408	207	0.0490584
Rv3019c	Cell wall and cell processes	71224.33	0.08889492	167	0.0488181	3H6P
Rv0311	Conserved hypotheticals	67942.516	0.07391167	156	0.048861504
Rv0556	Cell wall and cell processes	66400.05	0.103606604	193	0.049006738
Rv0451c	Cell wall and cell processes	66230.336	0.09615834	171	0.04883437	2LW3
Rv0288	Cell wall and cell processes	63475.453	0.09102694	170	0.048855472	2KG7
Rv0875c	Cell wall and cell processes	49197.566	0.11939961	197	0.04895823
Rv1274	Cell wall and cell processes	46747.54	0.11324064	197	0.04900249
Rv0817c	Cell wall and cell processes	40821.99	0.11914455	196	0.048973985
Rv0358	Conserved hypotheticals	40230.57	0.07967692	154	0.048827738