Comparative Genome and Network Centrality Analysis to Identify Drug Targets of Mycobacterium tuberculosis H37Rv

Table 5

Sorted lists of proteins proposed as potential drug targets which have solved structure.

Protein	Network centrality scores				PDB
	Betweenness	Eigenvector	Degree	Closeness
Rv3019c	71224.33	0.08889492	167	0.0488181	3H6P
Rv0451c	66230.336	0.09615834	171	0.0488344	2LW3
Rv0288	63475.453	0.09102694	170	0.0488555	2KG7
Rv0058	57680.18	0.00275039	62	0.0481486	2R5U
Rv1908c	50548.035	0.00563762	76	0.0484564	1SFZ; 1SJ2; 2CCA; 2CCD; 4C50; 4C51
Rv2050	40088.305	0.01941196	91	0.0485105	2M4V; 2M6P
Rv2150c	37525.4	0.00763293	103	0.0484339	1RLU; 1RQ2; 1RQ7; 2Q1X; 2Q1Y; 4KWE
Rv3793	36733.14	0.06872068	136	0.0487904	3PTY
Rv2111c	35411.24	0.00444417	37	0.0479427	3M91; 3M9D
Rv0002	33375.504	0.00362037	90	0.0482796	3P16; 3RB9
Rv3597c	27758.719	0.01894281	73	0.048406	2KNG; 4E1P; 4E1R
Rv1837c	24302.383	0.00201247	47	0.0479375	2GQ3; 3S9I; 3S9Z; 3SAD; 3SAZ; 3SB0
Rv0467	23928.854	0.00293969	53	0.0481574	1F61; 1F8I; 1F8M
Rv3240c	22790.56	0.00369075	64	0.0481586	1NKT; 1NL3
Rv0216	20616.273	0.01939864	57	0.0482126	2BI0
Rv1611	17798.758	0.00289133	57	0.0481961	3QJA; 3T40; 3T44; 3T55; 3T78; 4FB7
Rv2773c	17351.877	0.00189925	52	0.0480259	1C3V; 1P9L; 1YL5; 1YL6; 1YL7
Rv0902c	16640.244	0.02111599	42	0.0480668	1YS3; 1YSR
Rv2711	15661.199	0.00590289	41	0.0481721	1B1B; 1FX7; 1U8R; 2ISY; 2ISZ; 2IT0
Rv3601c	15341.172	0.00251573	49	0.0481235	2C45
Rv2518c	14995.93	0.00281853	25	0.0477322	3VYN; 3VYO; 3VYP; 4GSQ; 4GSR; 4GSU; 4HU2; 4HUC
Rv0736	14264.871	0.01536277	50	0.0483009	3HUG
Rv2538c	14206.7705	0.00232458	65	0.0481065	3QBD; 3QBE
Rv3808c	13873.782	0.00814938	51	0.0480131	4FIX; 4FIY
Rv2416c	13419.646	0.00771849	39	0.0482891	3R1K; 3RYO; 3SXO; 3UY5
Rv2987c	13133.913	0.0017555	52	0.0479834	3H5E; 3H5H; 3H5J
Rv2986c	13109.861	0.00315177	40	0.0481223	4DKY; 4PT4
Rv2391	12401.702	0.00120635	45	0.0478749	1ZJ8; 1ZJ9