Antiproliferative Activity of Flavonoids from Croton sphaerogynus Baill. (Euphorbiaceae)

Table 2

Antiproliferative activity (GI₅₀, g/mL) of the leaf extract and fractions of Croton sphaerogynus on culture cell lines.

Material tested	Cell lines^a			Mean log
	U251	MCF-7	NCI-H460
Doxorubicin^b	<0.025	<0.025	<0.025	−1.60 P
EE	23.4	53.4	3.00	1.19 W
MP	8.10	20.0	0.25	0.54 M
HP	24.7	27.2	3.80	1.14 W
F1	16.7	20.3	1.20	1.19 W
F2	41.8	61.1	12.3	1.50 W
F3	58.7	47.0	12.4	1.51 I
F4	15.0	8.10	11.8	1.05 M
F5	31.6	17.9	21.8	1.36 W

U251: glioma; MCF-7: breast cancer; NCI-H460: nonsmall cell lung.
^bPositive control. NCI’s criteria (Fouche et al., 2008 [23]): I: mean log GI₅₀ > 1.5 = inactive; W: weak activity: mean log GI₅₀ > 1.1–1.5; M: moderate activity: mean log GI₅₀ > 0–1.1; P: potent activity: mean log GI₅₀ < 0.
^clog GI₅₀.
Crude EtOH extract (EE); MeOH (MP) and hexane (HP) phases, and fractions (F1, F2, F3, F4, and F5).