Assessing Apoptosis Gene Expression Profiling with a PCR Array in the Hippocampus of Ts65Dn Mice

Figure 1

The morphological changes in the hippocampus of Ts65Dn mice observed by TEM. (a) Normal hippocampus tissues in control mice showing typical synaptic and normal cell structure, including normal cell nuclear shapes, distributed chromatin, abundant organelles, dense mitochondria, and flat Golgi apparatus. (b) In Ts65Dn mice the nuclear membrane became thin, chromosomes appeared unevenly distributed, and chromatin crescents were produced. (c) The nuclei exhibited pyknosis and nuclear fragmentation. (d) The cell wall began to sag and cell atrophy was observed.

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