Performance of Three Multipurpose Disinfecting Solutions with a Silicone Hydrogel Contact Lens

Table 4

Summarized overview of different studies comparing MPDS.

Study	Sample size	Materials	MPDSs	Outcome measures	Main conclusions
Duench et al. (2013) [47]	15 CL; 10 controls	Purevision	ReNu Fresh; OPTI-FREE Express	Fluorophotometry	No differences
				Corneal staining	Higher staining with ReNu
De La Jara et al. (2013) [37]	252 subjects	Acuvue Oasys	AQuify; ReNu Multiplus; OPTI-FREE Express; OPTI-FREE Replenish	Comfort at insertion	No differences
				End-of-day comfort; End-of-day dryness	Higher comfort and less dryness with; MPDSs that contain PHMB than that contain Polyquad
				SICS	No differences between PHMB and Polyquad
González-Méijome; et al. (2013) [31]	25 subjects	Air Optix Aqua	COMPLETE RevitaLens; Biotrue	NIBUT	No differences
				Comfort	No differences
Campbell et al.; (2012) [11]	573 subjects	Not specified	PureMoist; ReNu Fresh	Comfort	Better with PureMoist
				Corneal staining	Lower with PureMoist
				Deposits	Less with PureMoist
Martin et al. (2011) [38]	54 subjects	Air Optix	Solo-care Aqua; Hidro Health	Corneal edema; Endothelial regularity, corneal staining, neovascularization and infiltrates, limbal/bulbar injection, tarsal abnormalities	No differences
				Subjective comfort, average daily wearing time, lens centration, lens deposits, wettability	No differences
Keir et al. (2010) [41]	26 subjects	Air Optix; Acuvue OASYS	AOSept Plus; OPTI-FREE Replenish	Corneal and conjunctival staining	No differences
				Comfort	AOSept Plus longer comfortable wearing time than OPTI-FREE Replenish
Santodomingo-Rubido et al. (2008) [43]	18 subjects	Premio; Acuvue Oasys	MeniCare Soft; Complete; OPTI-FREE Express	Corneal staining	No differences between MPDSs
Brautaset et al.; (2008) [42]	338 subjects	Focus N&D; Focus Dailies; Acuvue 2; Air Optix; Acuvue Advance; Freshlook; Acuvue Oasys; and others	OPTI-FREE (Express & Replenish); ReNu Multiplus; Complete Moisture Plus; Clear Care and others	Corneal and conjunctival staining	Conjunctival staining more frequent than corneal staining; No differences between CLs or MPDSs
Andrasko and Ryen; (2008) [45]	30 subjects	Acuvue 2; Proclear; SofLens 66; PureVision; Acuvue Advance; Acuvue Oasys; O2Optix; Night & Day; Biofinity	Unisol 4 Saline Clear Care; OPTI-FREE Express; OPTI-FREE Replenish; ReNu with Moistureloc; ReNu Multiplus; Wal-Mart MPS; Target MPS; Complete MoisturePLUS; AQuify	Corneal staining	OPTI-FREE Express, OPTI-FREE Replenish, and Clear Care exhibited minimal corneal staining area.
Zigler et al. (2007) [39]	233 subjects	Focus N&D; Acuvue Advance	OPTI-FREE Replenish; ReNu Multiplus; Complete MoisturePLUS	Comfort at day 30; Corneal staining; Rewetting drop use	No diff. between MPDS; Higher staining with ReNu; Higher with complete
Stiegemeier et al.; (2006) [46]	362 subjects	Acuvue 2; Biomedics 55; Focus 1-2 weeks; Frequency 55 Toric; Acuvue; Biomedics Toric; Focus Toric; Others	OPTI-FREE Replenish; ReNu Multiplus	Comfort; Corneal staining; Deposits	Higher comfort with OPTI-FREE Replenish compared to ReNu Multiplus; Lower corneal staining with OPTI-FREE Replenish; Less deposits with OPTI-FREE Replenish
Stiegemeier et al.; (2004) [44]	231 subjects	SofLens; Surevue	OPTI-FREE Express; ReNu Multiplus	Comfort and satisfaction	Higher comfort and satisfaction with OPTI-FREE Express compared to ReNu Multiplus
				Corneal staining	Higher corneal staining with SofLens and ReNu combinations
				Deposits	OPTI-FREE Express tended to be better at maintaining lens cleanliness compared to ReNu Multiplus
Pritchard et al.; (2003) [25]	24 subjects	SofLens 66; (alphafilcon A)	OPTI-FREE Express; ReNu Multi-Purpose Solution; ReNu Multiplus	Corneal staining	Less staining area with OPTI-FREE Express

Only measures of interest for the purpose of the present study are reported.
ReNu Moistureloc not assayed with all brands due to withdrawal of the product before the end of the study.