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BioMed Research International
Volume 2015, Article ID 217593, 16 pages
http://dx.doi.org/10.1155/2015/217593
Review Article

Targeted Therapies in Adult B-Cell Malignancies

1Department of Hematology, University Hospital, CHU Saint Eloi, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 05, France
2Université Montpellier I, UFR Médecine, 34396 Montpellier, France

Received 13 March 2015; Revised 3 May 2015; Accepted 5 May 2015

Academic Editor: Haiqing Ma

Copyright © 2015 Jean-François Rossi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

B-lymphocytes are programmed for the production of immunoglobulin (Ig) after antigen presentation, in the context of T-lymphocyte control within lymphoid organs. During this differentiation/activation process, B-lymphocytes exhibit different restricted or common surface markers, activation of cellular pathways that regulate cell cycle, metabolism, proteasome activity, and protein synthesis. All molecules involved in these different cellular mechanisms are potent therapeutic targets. Nowadays, due to the progress of the biology, more and more targeted drugs are identified, a situation that is correlated with an extended field of the targeted therapy. The full knowledge of the cellular machinery and cell-cell communication allows making the best choice to treat patients, in the context of personalized medicine. Also, focus should not be restricted to the immediate effects observed as clinical endpoints, that is, response rate, survival markers with conventional statistical methods, but it should consider the prediction of different clinical consequences due to other collateral drug targets, based on new methodologies. This means that new reflection and new bioclinical follow-up have to be monitored, particularly with the new drugs used with success in B-cell malignancies. This review discussed the principal aspects of such evident bioclinical progress.