Targeted Therapies in Adult B-Cell Malignancies

Figure 1

Surface markers of B-cell lineage present at the principal stages of differentiation, as targets for therapy. TdT: terminal deoxynucleotide transferase. TACI/BCMA: transmembrane activator and CAML interactor/B-cell maturation antigen. IGF-1R: insulin growth factor-1 receptor. EGFR: epithelial growth factor receptor. VEGFR: vascular endothelial growth factor receptor. IL6R: interleukin 6 receptor. FGFR3: fibroblast growth factor receptor type 3. c-Kit: CD117. BCR: B-cell receptor.