Review Article
Targeted Therapies in Adult B-Cell Malignancies
Table 1
Clinical trials for B-cell chronic lymphocytic leukemia (B-CLL), lymphoma (NHL = non-Hodgkin’s lymphoma), and multiple myeloma, based on research made by using key words for the different diseases, through https://clinicaltrials.gov/, as of March 13, 2015. VEGF: vascular endothelial growth factor; EGFR: epithelial growth factor; IGF-1 R: insulin growth factor receptor type 1; BTK: Bruton’s tyrosine kinase; PI3k: phosphoinositide 3-kinase; HDAC: histone deacetylase; CAR-T: chimeric antigen receptor-T lymphocytes; Cdk: cyclin-dependent kinase; DKK: Dickkopf-related protein; ADCC = antibody-dependent cell cytotoxicity; CDC = complement-dependent cytotoxicity; A = direct apoptosis; M = mouse; H = humanized; Ch = chimeric; C = cytotoxicity; Phag. = phagocytosis; Doxo. = doxorubicin; Cytotox. = cytotoxicity.
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