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BioMed Research International
Volume 2015, Article ID 217961, 5 pages
Research Article

Oligoclonal Bands in Cerebrospinal Fluid of Black Patients with Multiple Sclerosis

1Pontifical Catholic University of São Paulo, Rua Conde Fco Matarazzo 58, 18030-010 Sorocaba, SP, Brazil
2University of São Paulo, São Paulo, SP, Brazil
3Hospital Sírio-Libanês, São Paulo, SP, Brazil
4Federal University of Uberlândia, MG, Brazil
5Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
6Metropolitan University of Santos, Santos, SP, Brazil
7Demyelinating Diseases Reference Center, Hospital das Clinicas, University of São Paulo, São Paulo, SP, Brazil

Received 11 October 2014; Revised 21 May 2015; Accepted 3 June 2015

Academic Editor: Bernd L. Fiebich

Copyright © 2015 Paulo Diniz da Gama et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Genetic susceptibility is a well-recognized factor in the onset of multiple sclerosis (MS). The objective of this study was to determine the frequency of oligoclonal bands (OCB) restricted to the cerebrospinal fluid, in an ethnically mixed group of MS patients in the city of São Paulo, Brazil. Techniques used to detect OCB consisted of isoelectric focusing followed by immunoblotting. OCB were found in 49 (54.4%) out of 90 patients with clinically definite MS; out of the 23 brown/black patients, 17 (73.9%) were OCB+; out of the 66 white patients, 32 (48.5%) were OCB+; and the only patient yellow was OCB+ (). Analysis of the IgG index was also consistent with the findings, but with lower statistical significance. The data presented in our study show that the ethnic differences in MS extend to the immune response.