Figure 4: Images from a 71-year-old male with a history of chest pain and hemoptysis. (a) B-mode sonogram showed a hypoecho lesion (M) in middle lobe of right lung. (b) CEUS obtained 56 seconds after injection of SonoVue showed an irregular necrosis in the majority of lesions () and only small area (M) had slight enhancement in the border. (c) US-guided transthoracic biopsy punctured through the necrosis area and targeted the enhanced area (). (d) Pathological result from biopsy demonstrated a poorly differentiated pulmonary adenocarcinoma with necrosis (hematoxylin-eosin, original magnification ×200).