Association between Genetic Polymorphisms of DNA Repair Genes and Chromosomal Damage for 1,3-Butadiene-Exposed Workers in a Matched Study in China
Table 5
Association between diplotypes of XRCC1 and the frequency of nucleus buds (NBUDs).
Name
β
95% CI
Adjusted FRa
Low
Upper
(95% CI)
Intercept
0.6047
−0.3894
1.5988
1.42
0.2332
Gender (female)
0.3118
−0.2169
0.8405
1.34
0.2478
1.37 (0.81–2.32)
Age (⩽40)
0.1287
−0.4292
0.6865
0.20
0.6512
1.14 (0.65–1.99)
OL
−0.1447
−0.6655
0.3760
0.30
0.5859
0.87 (0.51–1.46)
Smoking (no)
−0.0894
−0.5808
0.4021
0.13
0.7215
0.91 (0.56–1.49)
Drinking (no)
−0.3682
−0.8256
0.0891
2.49
0.1145
0.69 (0.44–1.09)
TCGG-TCGG
—
—
—
—
—
1
TCGG-CCGG
0.5219
−0.1652
1.2091
2.22
0.1366
1.69 (0.85–3.35)
TCGG-TCAG
0.2441
−0.4885
0.9767
0.43
0.5137
1.28 (0.61–2.66)
TCGA-CCGG
0.7404
0.0274
1.4534
4.14
0.0418
2.10 (1.03–4.28)*
TCGG-TCGA
1.0101
0.3804
1.6399
9.88
0.0017
2.75 (1.46–5.15)*
Others
0.3530
−0.2696
0.9757
1.23
0.2665
1.42 (0.76–2.65)
The diplotype is defined as the allele present at positions −77 (C/T), 194 (C/T), 280 (G/A),and 399 (G/A), respectively. Others: grouping of all diplotypes with <5% frequency. aMultiple Poisson regression: FR adjusted by age, gender, smoking, and occupational longevity (OL). *P < 0.05.
