Bone Regeneration of Hydroxyapatite/Alumina Bilayered Scaffold with 3 mm Passage-Like Medullary Canal in Canine Tibia Model

Figure 4

Fluorescence microscopic images of segmental defect sites treated with 3 mm passage ((a)–(c)) or without passage ((d)–(f)) scaffold in beagle tibiae at eight weeks after implantation. (a) and (d) nonstained images. (b) and (e) Green color (calcein) indicates new bone formation at six weeks after implantation on the confocal microscopy. (c) and (f) Red color (alizarin red S) indicates new bone formation at eight weeks following implantation on the confocal microscopy. Arrows indicate a scaffold.

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