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BioMed Research International
Volume 2015 (2015), Article ID 235709, 6 pages
http://dx.doi.org/10.1155/2015/235709
Review Article

A Low-Dose Combination of Fluvastatin and Valsartan: A New “Drug” and a New Approach for Decreasing the Arterial Age

Department of Vascular Diseases, University of Ljubljana Medical Centre, Zaloška Cesta 7, 1000 Ljubljana, Slovenia

Received 11 July 2014; Accepted 27 October 2014

Academic Editor: Nicole Clarke

Copyright © 2015 Miodrag Janić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. G. Robinson and S. S. Gidding, “Curing atherosclerosis should be the next major cardiovascular prevention goal,” Journal of the American College of Cardiology, vol. 63, no. 25PA, pp. 2779–2785, 2014. View at Publisher · View at Google Scholar
  2. S. C. Smith Jr., D. Chen, A. Collins et al., “Moving from political declaration to action on reducing the global burden of cardiovascular diseases: a statement from the global cardiovascular disease taskforce,” Circulation, vol. 128, no. 23, pp. 2546–2548, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Janić, M. Lunder, and M. Šabovič, “A new anti-ageing strategy focused on prevention of arterial ageing in the middle-aged population,” Medical Hypotheses, vol. 80, no. 6, pp. 837–840, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Lunder, M. Janić, S. Habjan, and M. Šabovič, “Subtherapeutic, low-dose fluvastatin improves functional and morphological arterial wall properties in apparently healthy, middle-aged males—a pilot study,” Atherosclerosis, vol. 215, no. 2, pp. 446–451, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Lunder, M. Janić, and M. Šabovič, “Reduction of age-associated arterial wall changes by low-dose valsartan,” European Journal of Preventive Cardiology, vol. 19, no. 6, pp. 1243–1249, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Lunder, M. Janić, B. Jug, and M. Šabovič, “The effects of low-dose fluvastatin and valsartan combination on arterial function: a randomized clinical trial,” European Journal of Internal Medicine, vol. 23, no. 3, pp. 261–266, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. V. Savic, B. Erzen, M. Janic et al., “Improvement of arterial wall characteristics by the low-dose fluvastatin and valsartan combination in type 1 diabetes mellitus patients,” Diabetes and Vascular Disease Research, vol. 10, no. 5, pp. 420–425, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. R. A. Payne, “Cardiovascular risk,” British Journal of Clinical Pharmacology, vol. 74, no. 3, pp. 396–410, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. J. H. Stein, M. C. Fraizer, S. E. Aeschlimann, J. Nelson-Worel, P. E. McBride, and P. S. Douglas, “Vascular age: integrating carotid intima-media thickness measurements with global coronary risk assessment,” Clinical Cardiology, vol. 27, no. 7, pp. 388–392, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. J. I. Cuende, N. Cuende, and J. Calaveras-Lagartos, “How to calculate vascular age with the SCORE project scales: a new method of cardiovascular risk evaluation,” European Heart Journal, vol. 31, no. 19, pp. 2351–2358, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. D. B. Santana, Y. A. Zócalo, I. F. Ventura et al., “Health informatics design for assisted diagnosis of subclinical atherosclerosis, structural, and functional arterial age calculus and patient-specific cardiovascular risk evaluation,” IEEE Transactions on Information Technology in Biomedicine, vol. 16, no. 5, pp. 943–951, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. E. K. Kerut, “Coronary risk assessment and arterial age calculation using coronary artery calcium scoring and the framingham risk score,” Echocardiography, vol. 28, no. 6, pp. 686–693, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Ebeling and P. Nischan, “Nonexperimental evaluation of the effectiveness of a screening program for lung cancer,” International Journal of Technology Assessment in Health Care, vol. 8, no. 2, pp. 245–254, 1992. View at Publisher · View at Google Scholar · View at Scopus
  14. J. A. Munir, H. Wu, K. Bauer et al., “Impact of coronary calcium on arterial age and coronary heart disease risk estimation using the MESA arterial age calculator,” Atherosclerosis, vol. 211, no. 2, pp. 467–470, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. R. B. D'Agostino Sr., R. S. Vasan, M. J. Pencina et al., “General cardiovascular risk profile for use in primary care: the Framingham heart study,” Circulation, vol. 117, no. 6, pp. 743–753, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Jankowski, M. E. Safar, and A. Benetos, “Pleiotropic effects of drugs inhibiting the renin-angiotensin-aldosterone system,” Current Pharmaceutical Design, vol. 15, no. 5, pp. 571–584, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. C. G. Mihos, M. J. Salas, and O. Santana, “The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in cardiovascular disease: a comprehensive review,” Cardiology in Review, vol. 18, no. 6, pp. 298–304, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Wang, R. E. Monticone, and E. G. Lakatta, “Arterial aging: a journey into subclinical arterial disease,” Current Opinion in Nephrology and Hypertension, vol. 19, no. 2, pp. 201–207, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Z. I. Cherney, J. W. Scholey, S. Jiang et al., “The effect of direct renin inhibition alone and in combination with ACE inhibition on endothelial function, arterial stiffness, and renal function in type 1 diabetes,” Diabetes Care, vol. 35, no. 11, pp. 2324–2330, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. A. M. El-Barbary, M. S. Hussein, E. M. Rageh, H. E. Hamouda, A. A. Wagih, and R. G. Ismail, “Effect of atorvastatin on inflammation and modification of vascular risk factors in rheumatoid arthritis,” Journal of Rheumatology, vol. 38, no. 2, pp. 229–235, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. R. G. Fassett, I. K. Robertson, M. J. Ball, D. P. Geraghty, J. E. Sharman, and J. S. Coombes, “Effects of atorvastatin on arterial stiffness in chronic kidney disease: a randomised controlled trial,” Journal of Atherosclerosis and Thrombosis, vol. 17, no. 3, pp. 235–241, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Hayashi, K. Miyagawa, K. Sato, R. Ueda, and Y. Dohi, “Temocapril, an angiotensin converting enzyme inhibitor, ameliorates age-related increase in carotid arterial stiffness in normotensive subjects,” Cardiology, vol. 106, no. 3, pp. 190–194, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Hongo, S. Kumazaki, A. Izawa et al., “Low-dose rosuvastatin improves arterial stiffness in high-risk Japanese patients with dyslipdemia in a primary prevention group: a comparison with fluvastatin,” Circulation Journal, vol. 75, no. 11, pp. 2660–2667, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Ichihara, M. Hayashi, Y. Kaneshiro et al., “Low doses of losartan and trandolapril improve arterial stiffness in hemodialysis patients,” American Journal of Kidney Diseases, vol. 45, no. 5, pp. 866–874, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. R. C. Pasternak, S. C. Smith Jr., C. N. Bairey-Merz, S. M. Grundy, J. I. Cleeman, and C. Lenfant, “ACC/AHA/NHLBI clinical advisory on the use and safety of statins,” Journal of the American College of Cardiology, vol. 40, no. 3, pp. 567–572, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Burnier, “Angiotensin II type 1 receptor blockers,” Circulation, vol. 103, no. 6, pp. 904–912, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Zhou, M. Cheng, Y. H. Liao et al., “Rosuvastatin enhances angiogenesis via eNOS-dependent mobilization of endothelial progenitor cells,” PLoS ONE, vol. 8, no. 5, Article ID e63126, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. S. H. Han, E. W. Kang, S.-J. Yoon et al., “Combined vascular effects of HMG-CoA reductase inhibitor and angiotensin receptor blocker in non-diabetic patients undergoing peritoneal dialysis,” Nephrology Dialysis Transplantation, vol. 26, no. 11, pp. 3722–3728, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Horiuchi, T.-X. Cui, Z. Li, J.-M. Li, H. Nakagami, and M. Iwai, “Fluvastatin enhances the inhibitory effects of a selective angiotensin II type 1 receptor blocker, valsartan, on vascular neointimal formation,” Circulation, vol. 107, no. 1, pp. 106–112, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. O. Hussein, J. Shneider, M. Rosenblat, and M. Aviram, “Valsartan therapy has additive anti-oxidative effect to that of fluvastatin therapy against low-density lipoprotein oxidation: studies in hypercholesterolemic and hypertensive patients,” Journal of Cardiovascular Pharmacology, vol. 40, no. 1, pp. 28–34, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Liu, S.-P. Zhao, H.-N. Zhou, Q.-Z. Li, and J.-X. Li, “Effect of fluvastatin and valsartan, alone and in combination, on postprandial vascular inflammation and fibrinolytic activity in patients with essential hypertension,” Journal of Cardiovascular Pharmacology, vol. 50, no. 1, pp. 50–55, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Lunder, L. Žiberna, M. Janić et al., “Low-dose atorvastatin, losartan, and particularly their combination, provide cardiovascular protection in isolated rat heart and aorta,” Heart and Vessels, vol. 28, no. 2, pp. 246–254, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Janić, M. Lunder, M. Prezelj, and M. Šabovič, “A combination of low-dose fluvastatin and valsartan decreases inflammation and oxidative stress in apparently healthy middle-aged males,” Journal of Cardiopulmonary Rehabilitation and Prevention, vol. 34, no. 3, pp. 208–212, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Carerj, C. Nipote, C. Zimbalatti et al., “388 normal vascular aging evaluated by a new tool: e-tracking,” European Heart Journal—Cardiovascular Imaging, vol. 7, supplement 1, p. S49, 2006. View at Publisher · View at Google Scholar
  35. M.-J. Jurašić, S. Josef-Golubić, R. Šarac, A. Lovrencic-Huzjan, and V. Demarin, “Beta stiffness—setting age standards,” Acta Clinica Croatica, vol. 48, no. 3, pp. 253–258, 2009. View at Google Scholar · View at Scopus
  36. M. Janić, M. Lunder, and M. Šabovič, “Arterial stiffness and cardiovascular therapy,” BioMed Research International, vol. 2014, Article ID 621437, 11 pages, 2014. View at Publisher · View at Google Scholar
  37. M. Lunder, G. Drevenšek, D. Černe, J. Marc, M. Janić, and M. Šabovič, “Treatment with low-dose atorvastatin, losartan, and their combination increases expression of vasoactive-related genes in rat aortas,” Journal of Cardiovascular Pharmacology and Therapeutics, vol. 18, no. 2, pp. 177–183, 2013. View at Publisher · View at Google Scholar · View at Scopus