Pim-2/mTORC1 Pathway Shapes Inflammatory Capacity in Rheumatoid Arthritis Synovial Cells Exposed to Lipid Peroxidations

Figure 1

4-HNE inactivates mTORC1 activity in MH7A rheumatoid arthritis synovial cells. (a-b) Western blots and histograms showing the decreased mTORC1 activity (indicated by pp70S6K/p70S6K and p4EBP1/4EBP1) by 4-HNE treatment in MH7A synovial cells. (c) Images showing that pp70S6K signals were decreased by 4-HNE treatment in MH7A synovial cells. Green fluorescence indicates pp70S6K, and blue indicates DAPI. Bar 25 μm. Results are averages of three independent experiments. Data represent mean ± SEM. , , and .

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