Pim-2/mTORC1 Pathway Shapes Inflammatory Capacity in Rheumatoid Arthritis Synovial Cells Exposed to Lipid Peroxidations

Figure 4

Pim-2 mediated mTORC1 activation inhibits HNE-induced inflammation in MH7A synovial cells. (a-b) Western blots and histograms showing that Pim-2 overexpression inhibited NF-κB nuclear localizations and COX-2 expressions under basal and 4-HNE conditions. (c) Histograms showing that Pim-2 overexpression inhibited TNF-α transcriptions under basal and 4-HNE conditions. Results are averages of three independent experiments. Data represent mean ± SEM. , , and .

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