Impact of Volatile Anesthetics on Oxidative Stress and Inflammation

Table 1

Effects of volatile anesthetics on oxidative stress and inflammation in cells.

Disease model	Stimulus	Cells	Anesthetics	Effect	Reference
Sepsis	LPS	HUVEC (human)	Sevoflurane	Anti-inflammatory effects	[27]
Acute lung injury	LPS	AEC (rat)	Sevoflurane	Anti-inflammatory effects	[28]
MODS	Zymosan	Kupffer cells (murine)	Isoflurane	Antioxidant effects	[18]
				Anti-inflammatory effects
Inflammation	TNF-	Monocytic THP-1 (human)	Sevoflurane, isoflurane	Anti-inflammatory effects	[29]
POCD	LPS	Microglial BV-2 (murine)	Sevoflurane, isoflurane	No effect on cytokine levels	[30]
Neuron injury	OGD	SH-SY5Y (human)	Isoflurane	Increased neuronal cell death	[31]

LPS, lipopolysaccharides; HUVEC, human vascular endothelial cells; AEC, alveolar epithelial cells; MODS, multiple organ dysfunction syndrome; TNF-, tumor necrosis factor-, POCD, postoperative cognitive dysfunction; OGD, oxygen-glucose deprivation.