Impact of Volatile Anesthetics on Oxidative Stress and Inflammation

Table 3

Effects of volatile anesthetics on oxidative stress and inflammation in humans.

Subject of study	Anesthetics	Effects	References
Patients; (elective lower abdominal surgery)	Isoflurane, sevoflurane	Increased DNA damage	[43]
Patients; (orthopedic surgery)	Sevoflurane	Increased DNA damage	[44]
Patients; (elective hysterectomy)	Isoflurane	Increased inflammation response	[45]
Patients; (elective cholecystectomy)	Isoflurane	Increased inflammation response	[46]
Patients; (elective thoracotomy lobectomy)	Sevoflurane	Pulmonary dysfunction by increased inflammation response	[47]
Patients; (otorhinological surgery)	Isoflurane, sevoflurane	No alteration of DNA damage	[48]
Patients; (otorhinological surgery)	Isoflurane	No alteration of DNA damage	[49]
Patients; (abdominal surgery)	Sevoflurane	Antioxidant activity	[50]
Patients; (otorhinological surgery)	Isoflurane	No induction of oxidative stress	[51]
		No induction of inflammation
Patients; (otorhinological surgery)	Sevoflurane	No alteration of redox state	[52]
Patients; (open thoracic surgery)	Sevoflurane	Anti-inflammatory effects	[53]
Patients; (open thoracic surgery)	Sevoflurane	Anti-inflammatory effects	[54]
Patients; (otorhinological surgery)	Isoflurane, sevoflurane	No alteration of cytokine profiles	[55]
Operating room personnel	Sevoflurane	No alteration of DNA damage	[56]
Operating room personnel	Isoflurane	Increased DNA damage	[57]