Research Article
SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure
Figure 8
Effect of Atp2a2 heterozygosity on regulators of energy metabolism in HCM and HCM/HET hearts. Heart RNA from WT mice, mice expressing the Glu180Gly mutant -tropomyosin (HCM), and HCM/Atp2a2+/− double mutant (HCM/HET) mice was analyzed by RT-PCR. mRNA levels are shown for (a) peroxisome proliferator-activated receptor gamma (Pparγ); (b) fatty acid binding protein 3 (Fabp3); (c) the muscle-isoform of carnitine palmitoyltransferase 1 (Cpt1b); (d) acetyl CoA-carboxylase beta (Acacb); (e) acyl-CoA oxidase 1 (Acox1); and (f) the GLUT4 glucose transporter (Slc2a4). mRNA levels were normalized to Gapdh. Values are means ± SE. = at least 4 for each genotype. versus WT controls; versus HCM.
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