Effects of P-15 Peptide Coated Hydroxyapatite on Tibial Defect Repair In Vivo in Normal and Osteoporotic Rats

Figure 2

Microarchitectural changes during the induction of osteoporosis. Graphic presentation of the development of osteoporosis in ovariectomized rats. 12 rats were ovariectomized three months prior to the surgery for creating defect. Bone loss was expressed as mean for each parameter. Significantly deteriorated microarchitecture could be observed after 11 weeks, with reduction in bone volume fraction (BV/TV) 65.5% and connectivity density (CD) 77.5%, and more importantly these changes remained constant. Cortical thickness (CoTh), trabecular thickness (TrTh), and degree of anisotropy (DA).