Effects of P-15 Peptide Coated Hydroxyapatite on Tibial Defect Repair In Vivo in Normal and Osteoporotic Rats

Table 2

3D microarchitectural properties (mean ± SD) of cancellous bone in osteoporosis induction period.

	Bone volume fraction (%)	Bone surface density (mm^−1)	Bone surface-to-volume ratio (mm^−1)	Structure model index (—)	Connectivity density (mm^−3)	Trabecular separation (µm)	Degree of anisotropy (—)	Trabecular thickness (m)
D −90 ()	59.8 ± 5.8	18.84 ± 0.55	31.31 ± 3.88	−2.04 ± 1.37	1234.58 ± 113.57	0.07 ± 0.06	1.37 ± 0.03	0.07 ± 0.004
D −7 ()	20.5 ± 14.1	8.25 ± 5.11	43.78 ± 4.07	3.02 ± 1.01	278 ± 261.42	0.16 ± 0.06	1.45 ± 0.08	0.06 ± 0.003
D0 ()	20.2 ± 15	8.08 ± 5.33	43.97 ± 5.04	3.1 ± 1.18	274.69 ± 262.63	0.16 ± 0.06	1.44 ± 0.09	0.06 ± 0.004
ANOVA	P < 0.0001	P < 0.0001	P = 0.0001	P < 0.0001	P < 0.0001	P = 0.0017	P = 0.0265	P = 0.0006
Difference between groups	D −90 > D −7, D0	D −90 > D −7, D0	D −90 < D −7, D0	D −90 < D −7, D0	D −90 > D −7, D0	D −90 < D −7, D0	D −90 < D −7	D −90 > D −7, D0

D0 = day 0, D −7 = day −7, and D −90 = day −90 before bone surgery. Values are expressed as mean for group, measured on both hind legs ± standard deviation. NS = no significance. values < 0.05 are considered significant.