| | Author, year | Ref | Study population | Specimen | Analytical platform | Metabolite alteration | Key finding |
| | Fanos et al., 2014 | [66] | Newborn piglets | Urine |
1H-NMR | 15 metabolites | Resuscitation with 21% O2 improves cellular recovery |
| | Arduini et al., 2014 | [29] | Newborn piglets
(12–36 hours old) | Retinal & choroid tissue | UPLC-MS/MS | Lactate | ↓mitochondrial metabolites, anaerobic shift |
| | Murgia et al., 2013 | [31] | Newborn piglets | Urine |
1H-NMR | n-Phenylacetylglycine, alanine, acetoacetate, methanol, glucose, sarcosine, succinate, dimethylamine | Reoxygenation speed alters metabolite profile |
| | Solberg et al., 2013 | [35] | Newborn piglets
(12–36 hours old) | Retinal tissue | UPLC-QTOFMS
UPLC-MS/MS | CDP-choline, acetylcholine, and choline | Phospholipid synthesis involvement and neuroprotective metabolites |
| | Skappak et al., 2013 | [26] | Newborn piglets
(1–3 days old) | Urine |
1H-NMR | Amino acids, energy metabolites, 1-methylnicotinamide & betaine | Urinary metabolites identify hypoxia |
| | Liu et al., 2013 | [34] | Mice
(postnatal day 7) | Brain tissue |
1H-NMR | Energy metabolites, ATP-ADP, valine, phosphocholine, lactate, glucose, and glutamate | Hypothermia treatment alters metabolites |
| | Beckstrom et al., 2011 | [25] | Macaques | Plasma
(5 min after birth) | 2D GC/MS | 10 metabolites | Krebs cycle metabolites altered and cell membrane disturbance |
| | Solberg et al., 2010 | [24] | Newborn piglets | Plasma | LC-MS/MS
FIA-MS/MS | Alanine/BCAA, glycine/BCAA (correlation ), and carnitines | ↓Krebs cycle intermediates & delayed recovery with 100% O2 resuscitation |
| | Atzori et al., 2010 | [30] | Newborn piglets | Urine |
1H-NMR | Creatinine, methylguanidine, hydroxyisobutyric acid, urea, and malonate | Prediction of death |
| |
van Cappellen van Walsum et al., 2001 | [32] | Fetal lambs | CSF |
1H-NMR | Amino acids, BCAA, lactic acid, and hypoxanthine | Prolonged mild hypoxia leads to energy degradation |
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