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BioMed Research International
Volume 2015, Article ID 256580, 9 pages
Research Article

Candida Bloodstream Infections in Italy: Changing Epidemiology during 16 Years of Surveillance

Hygiene Section, Department of Biomedical Science and Human Oncology, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy

Received 4 December 2014; Revised 18 April 2015; Accepted 20 April 2015

Academic Editor: Handan Wand

Copyright © 2015 Giuseppina Caggiano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although considerable progress has been made in the management of patients with invasive fungal infections, Candida bloodstream infections are still widespread in hospital settings. Incidence rates vary geographically, often because of different patient populations. The aim of the present study was to describe the epidemiology of candidemia, to analyze the trend of species distribution, and to measure the in vitro susceptibility to antifungal drugs in a university Italian hospital from 1998 to 2013. The antifungal susceptibility for all Candida isolates was evaluated by broth microdilution assay (CLSI M27-A3 document). Of 394 episodes of candidemia, the average incidence was 3.06/10 000 admissions. C. albicans and non-albicans Candida species caused 44.2% and 55.8% of the episodes, respectively. C. parapsilosis (62.2%) was the most common non-albicans.  C. albicans predominated in almost all departments whereas C. parapsilosis was found in adult and paediatric oncohaematology units (34.8% and 77.6%, resp.). Overall, mortality occurred in 111 (28.2%) patients. Death occurred most often in intensive care units (47.1%) and specialist surgeries (43.7%). Most of the isolates were susceptible to antifungal drugs, but there was an upward trend for azole (). In conclusion, this study emphasizes the importance of monitoring local epidemiologic data and the diversity of patient groups affected.