Candida Bloodstream Infections in Italy: Changing Epidemiology during 16 Years of Surveillance

Table 4

In vitro susceptibility to the antifungal agents against 394 Candida isolates.

Species; (number of isolates)	Antifungal agent	MIC (µg/mL)
		Range	50%	90%
C. albicans (174)	Amphotericin B	0.06–1	0.50	1
	Fluconazole	0.06–2	0.25	1
	Voriconazole	≤0.008–0.5	0.008	0.25
	Posaconazole	≤0.008–0.5	0.03	0.25
	Anidulafungin	≤0.008–1	0.06	0.25
	Caspofungin	≤0.008–1	0.25	0.5
	Micafungin	≤0.008–0.5	0.03	0.06
C. parapsilosis (137)	Amphotericin B	0.06–1	0.25	0.5
	Fluconazole	0.06–8	0.5	1
	Voriconazole	≤0.008–1	0.015	0.06
	Posaconazole	≤0.008–2	0.125	0.25
	Anidulafungin	≤0.008–32	1	2
	Caspofungin	0.125–8	2	2
	Micafungin	≤0.008–32	1	2
C. glabrata (22)	Amphotericin B	0.25–1	0.5	1
	Fluconazole	2–32	8	16
	Voriconazole	0.03–2	0.25	1
	Posaconazole	0.25–4	0.25	4
	Anidulafungin	≤0.008–1	0.25	0.25
	Caspofungin	≤0.008–4	0.06	0.5
	Micafungin	≤0.008–1	0.06	0.5
C. guilliermondii (19)	Amphotericin B	0.125–1	0.25	1
	Fluconazole	0.5–4	4	4
	Voriconazole	≤0.008–1	0.06	0.5
	Posaconazole	0.125–1	0.5	1
	Anidulafungin	1–4	1	2
	Caspofungin	1–4	2	4
	Micafungin	0.5–2	1	2
C. tropicalis (19)	Amphotericin B	0.06–1	0.5	1
	Fluconazole	0.125–64	0.5	64
	Voriconazole	0.008–16	0.06	8
	Posaconazole	0.015–2	0.125	0.5
	Anidulafungin	0.03–0.25	0.25	0.25
	Caspofungin	≤0.008–2	0.06	1
	Micafungin	0.0015–1	0.25	0.5
C. krusei (11)	Amphotericin B	0.5–1	1	1
	Fluconazole	8–64	32	32
	Voriconazole	0.125–8	0.25	1
	Posaconazole	0.25–2	0.5	2
	Anidulafungin	≤0.008–0.5	0.25	0.5
	Caspofungin	0.06–2	0.25	1
	Micafungin	0.06–0.5	0.25	0.5