Molecular Analysis of AFP and HSA Interactions with PTEN Protein

Figure 5

Overall structure of HSA/FcRn complex and AFP-PTEN complex model. (a) X-ray structure of HSA/FcRn complex and (b) structure model of AFP in complex with PTEN. The binding interface was similar to HSA/FcRn complex. PTEN C2 domain was shown in green and phosphatase domain was shown in yellow. AFP (in blue) domain I binds to PTEN phosphatase domain, and domain III binds to C2 domain. PTEN phosphatase active site was wrapped by AFP domain I.

(a)

(b)