Neuroprotection in Preterm Infants

Figure 7

Neuronal cell damage in the cerebral cortex (A1–A5) and hippocampus (CA 1/2, CA3, DG) in neonatal rats following hypoxia-ischemia. The animals in the study group were treated with estradiol both before and after injury, whereas animals of the control group received NaCl. Neuronal cell damage was significantly reduced in the cerebral cortex as well as in the hippocampus after application of estradiol. Neuronal cell damage was evaluated using a scoring system (1 = 0%–4%; 2 = 5%–49%; 3 = 50%–94%; 4 = 95%–99%; 5 = 100% damaged neurons). Means ± SD (; ) [143].