Analysis of the Expression and Polymorphism of APOE, HSP, BDNF, and GRIN2B Genes Associated with the Neurodegeneration Process in the Pathogenesis of Primary Open Angle Glaucoma
Table 10
Analysis of BDNF expression level depending on the clinical parameters in patients with primary open angle glaucoma (POAG) for each eye counted.
Clinical parameter
Stage of POAG
Number of POAG
Mean (expression level − Ct)
SD (expression level − Ct)
Quartile 25%
Median
Quartile 75%
Normal (0–30)
53
19.43
1.43
18.47
19.46
20.43
NFI
Early (31–50)
13
19.34
1.03
18.89
19.50
19.84
0.681
Advanced (>51)
4
18.82
0.77
18.28
18.75
19.36
Normal (<0.3)
0
—
—
—
—
—
c/d
Early (0.3–0.7)
53
19.56
1.44
18.60
19.19
20.71
0.260
Advanced (>0.7)
50
19.18
1.28
18.16
19.09
19.89
RA
Normal (1.39–1.78)
33
20.33
1.25
19.06
19.67
20.65
0.011
Early (1.26–1.38)
9
19.94
1.52
18.87
19.50
21.50
Middle-advanced (0.81–1.25)
34
19.25
1.16
18.87
19.28
19.82
Advanced (<0.81)
9
18.68∧
1.50
17.76
18.21
18.91
RNFL
Normal (0.21–0.31)
39
19.79
1.34
18.94
19.62
20.59
0.360
Early (0.20–0.18)
7
19.82
1.48
19.28
19.83
20.39
Middle-advanced (0.13–0.17)
18
19.17
1.05
18.60
19.26
19.77
Advanced (<0.13)
21
19.40
1.47
18.21
19.06
19.82
NFI: nerve fiber index; c/d: cup disc ratio; RA: rim area; RNFL: retinal nerve fiber layer. Tukey’s HSD test: (∧normal versus advanced).
