Analysis of the Expression and Polymorphism of APOE, HSP, BDNF, and GRIN2B Genes Associated with the Neurodegeneration Process in the Pathogenesis of Primary Open Angle Glaucoma
Table 11
Analysis of HSP70-1 expression level depending on the clinical parameters in patients with primary open angle glaucoma (POAG) for each eye counted.
Clinical parameter
Stage of POAG
Number of POAG
Mean (expression level − Ct)
SD (expression level − Ct)
Quartile 25%
Median
Quartile 75%
Normal (0–30)
53
2.93
0.88
2.35
3.08
3.53
NFI
Early (31–50)
13
3.04
0.92
2.21
3.46
3.64
0.814
Advanced (>51)
4
2.73
0.62
2.49
2.76
2.99
Normal (<0.3)
0
—
—
—
—
—
c/d
Early (0.3–0.7)
53
2.96
0.89
2.21
2.97
3.73
0.121
Advanced (>0.7)
50
3.23
0.84
2.69
3.46
3.84
RA
Normal (1.39–1.78)
33
3.07
0.93
2.35
3.38
3.83
0.004
Early (1.26–1.38)
8
2.68
0.74
2.03
2.64
3.35
Middle-advanced (0.81–1.25)
34
2.85
0.85
2.21
3.01
3.53
Advanced (<0.81)
9
3.94
0.48
3.58
3.89
4.27
RNFL
Normal (0.21–0.31)
38
3.09
0.99
2.35
3.36
3.83
0.403
Early (0.20–0.18)
7
2.78
0.69
2.22
2.61
3.41
Middle-advanced (0.13–0.17)
19
2.80
0.83
2.01
2.84
3.51
Advanced (<0.13)
21
3.18
0.88
2.59
3.46
3.85
NFI: nerve fiber index; c/d: cup disc ratio; RA: rim area; RNFL: retinal nerve fiber layer. Tukey’s HSD test: (∧normal versus advanced; early versus advanced; #middle-advanced versus advanced).
