Analysis of the Expression and Polymorphism of APOE, HSP, BDNF, and GRIN2B Genes Associated with the Neurodegeneration Process in the Pathogenesis of Primary Open Angle Glaucoma
Table 13
Analysis of APOE expression level depending on the clinical parameters in patients with primary open angle glaucoma (POAG) for each eye counted.
Clinical parameter
Stage of POAG
Number of POAG
Mean (expression level - Ct)
SD (expression level - Ct)
Quartile 25%
Median
Quartile 75%
Normal (0–30)
53
12.55
3.88
10.42
11.32
12.68
NFI
Early (31–50)
12
11.24
0.94
10.50
10.89
12.20
0.735
Advanced (>51)
5
11.61
0.73
11.84
11.84
12.03
Normal (<0.3)
0
—
—
—
—
—
c/d
Early (0.3–0.7)
53
12.35
3.89
10.46
11.11
12.58
0.805
Advanced (>0.7)
50
12.09
2.91
10.87
11.12
11.98
RA
Normal (1.39–1.78)
38
11.55
2.52
10.45
11.07
11.67
0.412
Early (1.26–1.38)
6
14.92
6.27
10.76
11.67
19.39
Middle-advanced (0.81–1.25)
32
11.36
0.94
10.46
11.06
12.40
Advanced (<0.81)
9
11.53
0.39
11.24
11.68
11.86
RNFL
Normal (0.21–0.31)
46
11.72
2.43
10.78
11.07
12.18
0.875
Early (0.20–0.18)
6
11.51
1.01
10.46
11.49
12.58
Middle-advanced (0.13–0.17)
19
12.00
3.47
10.33
11.32
12.59
Advanced (<0.13)
20
11.51
1.98
10.56
11.22
11.60
NFI: nerve fiber index; c/d: cup disc ratio; RA: rim area; RNFL: retinal nerve fiber layer.
