Analysis of the Expression and Polymorphism of APOE, HSP, BDNF, and GRIN2B Genes Associated with the Neurodegeneration Process in the Pathogenesis of Primary Open Angle Glaucoma

Table 6

Analysis of HSP70-1 (rs1043618) gene polymorphism depending on the clinical parameters in patients with primary open angle glaucoma (POAG) for each eye counted.

Clinical parameter	Genotype	POAG patients	Mean	SD	Quartile 25%	Median	Quartile 75%
NFI	G/G	178	31.6	21.3	16.0	25.5	43.0	0.004
	G/C	183	26.3	17.8	16.0	23.0	29.0
	C/C	41	44.16^#	25.1	22.0	26.0	59.5
c/d	G/G	196	0.72	0.16	0.60	0.75	0.85	0.250
	G/C	313	0.71	0.16	0.60	0.75	0.80
	C/C	160	0.77	0.14	0.66	0.80	0.85
RA	G/G	232	1.21	0.38	0.95	1.24	1.47	0.009
	G/C	232	1.33	0.37	1.03	1.28	1.52
	C/C	58	1.08^#	0.47	0.73	1.10	1.41
RNFL	G/G	231	0.20	0.14	0.13	0.18	0.25	0.519
	G/C	232	0.21	0.20	0.13	0.19	0.27
	C/C	58	0.21	0.18	0.12	0.17	0.26

NFI: nerve fiber index; c/d: cup disc ratio; RA: rim area; RNFL: retinal nerve fiber layer.
Tukey’s HSD test: (^#G/C versus C/C).