Analysis of the Expression and Polymorphism of APOE, HSP, BDNF, and GRIN2B Genes Associated with the Neurodegeneration Process in the Pathogenesis of Primary Open Angle Glaucoma

Table 7

Analysis of GRIN2B (rs3764028) gene polymorphism depending on the clinical parameters in patients with primary open angle glaucoma (POAG) for each eye counted.

Clinical parameter	Genotype	POAG patients	Mean	SD	Quartile 25%	Median	Quartile 75%
NFI	C/C	364	29.9	19.8	16.0	25.0	37.0	0.339
	C/A	36	36.0	28.3	18.0	24.5	50.5
	A/A	2	12.5	14.8	2.00	12.5	23.0
c/d	C/C	609	0.72	0.16	0.60	0.75	0.85	0.124
	C/A	58	0.73	0.15	0.60	0.75	0.85
	A/A	2	0.50	0	0.50	0.50	0.50
RA	C/C	473	1.25	0.40	0.97	1.26	1.50	0.538
	C/A	47	1.18	0.36	0.92	1.23	1.43
	A/A	2	1.34	0.02	1.32	1.34	1.35
RNFL	C/C	472	0.20	0.17	0.12	0.19	0.26	0.434
	C/A	47	0.23	0.19	0.14	0.21	0.25
	A/A	2	0.20	0.01	0.20	0.20	0.21

NFI: nerve fiber index; c/d: cup disc ratio; RA: rim area; RNFL: retinal nerve fiber layer.