Analysis of the Expression and Polymorphism of APOE, HSP, BDNF, and GRIN2B Genes Associated with the Neurodegeneration Process in the Pathogenesis of Primary Open Angle Glaucoma
Table 8
Analysis of APOE (rs449647) gene polymorphism depending on the clinical parameters in patients with primary open angle glaucoma (POAG) for each eye counted.
Clinical parameter
Genotype
POAG patients
Mean
SD
Quartile 25%
Median
Quartile 75%
NFI
A/A
225
28.9
20.4
16.0
24.0
36.0
0.341
A/T
146
31.7
20.7
17.0
26.0
43.0
T/T
31
32.9
23.5
18.3
26.0
38.5
c/d
A/A
384
0.71
0.16
0.60
0.75
0.85
0.713
A/T
227
0.72
0.16
0.60
0.70
0.85
T/T
58
0.75
0.11
0.70
0.80
0.80
RA
A/A
298
1.24
0.39
0.95
1.24
1.48
0.620
A/T
178
1.28
0.42
1.03
1.26
1.48
T/T
46
1.21
0.33
1.01
1.29
1.46
RNFL
A/A
297
0.21
0.19
0.12
0.18
0.25
0.750
A/T
178
0.20
0.16
0.14
0.19
0.26
T/T
46
0.20
0.08
0.15
0.18
0.26
NFI: nerve fiber index; c/d: cup disc ratio; RA: rim area; RNFL: retinal nerve fiber layer.