Analysis of the Expression and Polymorphism of APOE, HSP, BDNF, and GRIN2B Genes Associated with the Neurodegeneration Process in the Pathogenesis of Primary Open Angle Glaucoma

Table 9

Comparison of mRNA expression in the blood of POAG with genotypes of genes. If differences between each genotype and others tested post hoc with Tukey’s HSD test.

Gene	Genotype	POAG patients	Mean	SD	Quartile 25%	Median	Quartile 75%
HSP70-1	G/G	20	2.77	0.85	2.12	2.68	3.62	0.016
	G/C	22	3.46^#	0.78	0.78	3.02	3.92
	C/C	6	3.51	0.64	3.32	3.47	3.52
BNDF	C/C	9	19.84	1.38	19.07	19.47	21.25	0.183
	C/T	32	19.52	1.43	18.57	19.55	20.43
	T/T	7	18.61	0.80	18.24	18.87	19.04
GRIN2B	C/C	44	18.02	1.94	16.57	18.29	19.46	0.325
	C/A	6	18.92	0.83	18.52	18.76	19.43
	A/A	—	—	—	—	—	—
APOE	A/A	32	12.46	3.52	10.89	11.33	12.65	0.267
	A/T	15	11.20	0.93	10.48	10.89	11.94
	T/T	1	12.59	—	12.59	12.59	12.59

Tukey’s HSD test: (G/G versus C/C, ^#G/G versus G/C).