Differentiation between Acute Skin Rejection in Allotransplantation and T-Cell Mediated Skin Inflammation Based on Gene Expression Analysis

Figure 5

Heat map visualizing mean log2-fold changes of cytokine/chemokine mRNA levels in two different inflammatory models (DTH, CHS) and two different skin types of allograft rejection at POD 5 in rat hind limb transplantation. Relative expressions are normalized to the mean of the controls from the respective group. Greater levels of inflammatory mediators (log2-fold changes > 0) are indicated in red and smaller levels (log2-fold changes < 0) are indicated in blue according to the legend. Similar profiles of mediators across all conditions are grouped by average linkage hierarchical clustering as indicated by the dendrogram (tree) at the left.