The Association between Charlson Comorbidity Index and the Medical Care Cost of Cancer: A Retrospective Study

Table 3

Association among associated diseases, CCI, and medical care cost based on medical records.

	Breast cancer		Colon cancer		Stomach cancer		Lung cancer
	β	95% CI		95% CI	β	95% CI	β	95% CI
Age group	1.08	0.94–1.24	1.01	0.95–1.08	0.95	0.91–0.99	0.95	0.90–1.00
Gender	—	—	1.06	0.98–1.15	1.03	0.98–1.08	0.94	0.84–1.05
Stage	1.06	1.00–1.12	1.10	1.06–1.15	1.09	1.07–1.11	1.09	1.03–1.16
Each comorbidity disease
MI	0.71	0.34–1.49	2.56	0.55–11.77	0.92	0.47–1.79	0.93	0.53–1.61
CHF	—	—	0.93	0.67–1.29	1.07	0.63–1.81	1.48	0.57–3.87
CVD	1.22	0.72–2.06	1.24	1.00–1.54	1.10	0.71–1.71	0.79^+	0.61–0.97
COPD	1.44^+	1.01–2.11	0.85	0.42–1.72	1.36	0.77–2.39	1.01	0.81–1.25
DM	1.04	0.50–2.15	1.06	0.27–4.27	0.91	0.70–1.18	0.98	0.82–1.16
Charlson Comorbidity Index
CCI	0.93	0.81–1.06	1.01	0.95–1.08	1.05	1.01–1.09	1.06^+	1.00–1.13
Interaction between CCI and each comorbidity^a
MI
CCI = 1	—	—	—	—	—	—	1.11	0.29–4.15
CCI = 2	—	—	—	—	—	—	1.20	0.69–2.07
CCI = 3	0.71	0.34–1.49	—	—	0.99	0.88–1.11	1.29	0.62–2.69
CHF
CCI = 1	—	—	—	—	—	—	0.77	0.43–1.36
CCI = 2	—	—	—	—	—	—	0.80	0.57–1.13
CCI = 3	—	—	—	—	0.96	0.86–1.06	0.84	0.48–1.47
CVD
CCI = 1	—	—	0.77	0.18–3.27	0.69	0.33–1.43	1.06	0.74–1.53
CCI = 2	1.22	0.96–1.56	0.82	0.42–1.61	0.83	0.58–1.20	1.04	0.83–1.31
CCI = 3	—	—	0.88	0.54–1.43	1.01	0.92–1.10	1.02	0.73–1.42
COPD
CCI = 1	1.23^+	0.96–1.56	0.88	0.48–1.61	1.07	0.75–1.53	0.99	0.87–1.14
CCI = 2	1.05	0.85–1.29	0.93	0.67–1.29	1.02	0.85–1.22	0.86	0.74–0.99
CCI = 3	0.89	0.65–1.23	0.98	0.78–1.24	0.97	0.92–1.02	0.74	0.59–0.93
DM
CCI = 1	—	—	1.35^+	1.01–1.91	1.24	0.89–1.73	1.14	0.70–1.85
CCI = 2	—	—	1.26	1.03–1.54	1.11	0.94–1.31	0.94	0.71–1.24
CCI = 3	1.04	0.50–2.15	1.18	1.00–1.40	0.99	0.94–1.04	0.77	0.54–1.10

< 0.05.
< 0.10.
Reference variable: CCI = 0.
MI, myocardial infarction; CHF, congestive heart failure; CVD, cerebrovascular disease; COPD, chronic obstructive pulmonary disease; DM, diabetes mellitus.