Coagulation Parameters and Risk of Progressive Hemorrhagic Injury after Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Table 5

Summary of the strength of coagulation tests in predicting PHI after traumatic brain injury.

Data type	Coagulation test	Number of studies	Population size	Fisher’s	Weighted	Range of effect size
Continuous	PLT	4	1003	−0.07	−0.06	−0.13–−0.003
	PT	2	630	0.10	—	—
	PTT	4	1026	0	—	—
	D-dimer	2	850	0.50	0.46	0.01–0.75
	Fg	3	1044	−0.13	−0.13	−0.23–−0.04
	INR	2	398	0.52	0.47	0.36–0.59
Dichotomous	PLT	4	1267	0.28	0.27	0.10–0.43
	PT	5	1654	0.34	0.33	0.16–0.48
	PTT	4	1289	0.29	—	—
	D-dimer	3	1160	0.80	0.66	0.44–0.81
	Fg	3	1145	0.31	0.30	0.22–0.38
	INR	2	512	0.37	0.35	0.27–0.42

APTT: activated partial thromboplastin time; Fg: fibrinogen/fibrin; INR: international normalized ratio; PHI: progressive hemorrhagic injury; PLT: platelet counts; PT: prothrombin time; .