Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma

Figure 3

Effects of BA in treating A/PR/8/34-infected IFN-γ or IFN-γ receptor KO mice. Mice were inoculated with virus intranasally and treated with 2.0 g/kg BA every 24 h for 14 days. Each group consists of 10 mice. Survival rate (a) of mice was observed in the next two weeks. ▲, untreated WT mice; ●, control A/PR/8/34-infected WT mice; ○, BA treated WT mice; , BA treated IFN-γ KO mice; □, BA treated IFN-γ receptor KO mice. (b) Lungs of mice were homogenized separately, diluted, and centrifuged on the third, fifth, and seventh day after infection, and the EID₅₀s were determined using 10 days’ chick embryo. (c) Lungs of mice were removed and examined pathologically using HE staining on the seventh day after infection. ^#Levels of significance of against untreated mice; against control infected mice; against control infected mice.

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