Study Year Purpose Population Histology/PR expression Intervention Outcome and results Conclusion
Olson et al. [22 ] 1986 3 Evaluation of hormonal stimulation and hormonal deprivation Human meningioma cell cultures Histology ns Exposition to 10−6 –10−10 M mifepristone for 28 d Mifepristone inhibits cell growth (18–36%) in all 3 specimens when compared to the control medium (Coulter counter) PRO Blankenstein et al. [23 ] 1989 30 cultures form 39 tissue specimens Evaluation of mifepristone as inhibitor of cell growth Human meningioma cell cultures PR expression measured but ns in the text Exposition to 10−6 –10−10 M mifepristone for 8 d Growth inhibition with mifepristone exposure (decrease in TLI, thymidine labeling index PRO Koper et al. [24 ] 1990 6 Effect of progesterone and mifepristone on the response to EGF Human meningioma cell cultures PR expression ns in 1 case 3 d incubation with 10−6 M mifepristone EGF-stimulated incorporation of thymidine was reduced with mifepristone exposure PRO Schrell et al. [25 ] 1989 23 Evaluation of effects of progesterone/mifepristone on cell growth Human meningioma cell cultures Varying degrees of PR expression Exposition to 10−6 –10−10 M mifepristone for 6–12 d No stimulating nor inhibitory effect was found CON Wilisch-Neumann et al. [26 ] 2014 4 (plus 3 other cell lines NF2wt and NF2ko) Efficacy of different chemotherapies/target therapies on meningioma cells growth Human meningioma cell lines: in vitro analysis 2 benign and 2 malignant meningiomas; PR expression ns Exposition to different mifepristone concentration, till 10−6 M Mifepristone showed some efficacy in growth inhibition only at very high doses and only in one cell line CON Matsuda et al. [27 ] 1994 13 meningioma cell cultures Antitumor effects of mifepristone and onapristone and relationship with PR expression Human meningioma tissue (13 specimens), previously untreated 9 meningothelial Exposition to 10−6 –10−10 M of antiprogestogen in vitro , evaluated at 9 d and 21 d Antitumor effects via PRs and/or another receptorIn vitro: cytostatic and cytocidal effects regardless of the presence of PRs (7/9 PR- responded)In vivo: reduction of tumor volume regardless of the presence of PR (no necrosis) PRO Olson et al. [28 ] 1987 6 nude mice, male athymic, divided into 2 groups Effect of mifepristone on meningioma implanted into nude mice 1 human meningioma implanted in the subcutaneous tissue of nude mice Meningothelial histology Mifepristone 10 mg/kg/d for 3 mo Disappearance of implanted meningioma nodules in 2/3 mice in 8–10 w; a small number of cells in the third case PRO
