Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 270973, 12 pages
http://dx.doi.org/10.1155/2015/270973
Research Article

In Vitro and In Vivo Cytogenotoxic Effects of Hot Aqueous Extract of Achyrocline satureioides (Lam.) DC.

1Departamento de Microbiología e Inmunología, Universidad Nacional de Río Cuarto, Ruta 36, Km 601, Río Cuarto, C5800 Córdoba, Argentina
2Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Rivadavia 1917, C1033AAJ Buenos Aires, Argentina
3Área de Microscopía Electrónica, Universidad Nacional de Río Cuarto, Ruta 36, Km 601, Río Cuarto, C5800 Córdoba, Argentina
4Farmacognosia, Departamento de Farmacia, Universidad Nacional de Córdoba (IMBIV-CONICET), Ciudad Universitaria, C5000 Córdoba, Argentina

Received 26 December 2014; Revised 1 February 2015; Accepted 1 February 2015

Academic Editor: Isabel C. F. R. Ferreira

Copyright © 2015 L. N. Cariddi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Alonso and C. Desmarchelier, “Plantas medicinales autóctonas de la Argentina,” in Bases Científicas para su Aplicación en Atención Primaria de la Salud, 2nd edition, 2006. View at Google Scholar
  2. K. C. B. de Souza, E. E. S. Schapoval, and V. L. Bassani, “LC determination of flavonoids: separation of quercetin, luteolin and 3-O-methylquercetin in Achyrocline satureioides preparations,” Journal of Pharmaceutical and Biomedical Analysis, vol. 28, no. 3-4, pp. 771–777, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Polydoro, K. C. B. de Souza, M. E. Andrades et al., “Antioxidant, a pro-oxidant and cytotoxic effects of Achyrocline satureioides extracts,” Life Sciences, vol. 74, no. 23, pp. 2815–2826, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. H. J. Kim, W. Lee, and J.-M. Yun, “Luteolin inhibits hyperglycemia-induced proinflammatory cytokine production and its epigenetic mechanism in human monocytes,” Phytotherapy Research, vol. 28, no. 9, pp. 1383–1391, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Y. Yang, C. J. Wang, N. F. Chen, W. H. Ho, F. J. Lu, and T. H. Tseng, “Luteolin enhances paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3,” Chemico-Biological Interactions, vol. 213, no. 1, pp. 60–68, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. L.-J. Zhang, S.-F. Yeh, Y.-T. Yu, L.-M. Kuo, and Y.-H. Kuo, “Antioxidative flavonol glucuronides and anti-hbsag flavonol from Rotala rotundifolia,” Journal of Traditional and Complementary Medicine, vol. 1, no. 1, pp. 57–63, 2011. View at Google Scholar · View at Scopus
  7. A. I. Matouk, A. Taye, G. H. Heeba, and M. A. El-Moselhy, “Quercetin augments the protective effect of losartan against chronic doxorubicin cardiotoxicity in rats,” Environmental Toxicology and Pharmacology, vol. 36, no. 2, pp. 443–450, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. J. V. Formica and W. Regelson, “Review of the biology of quercetin and related bioflavonoids,” Food and Chemical Toxicology, vol. 33, no. 12, pp. 1061–1080, 1995. View at Publisher · View at Google Scholar · View at Scopus
  9. C. A. Musonda and J. K. Chipman, “Quercetin inhibits hydrogen peroxide (H2O2)-induced NF-κB DNA binding activity and DNA damage in HepG2 cells,” Carcinogenesis, vol. 19, no. 9, pp. 1583–1589, 1998. View at Publisher · View at Google Scholar · View at Scopus
  10. I. Duarte Silva, J. Gaspar, G. Gomes Da Costa, A. S. Rodrigues, A. Laires, and J. Rueff, “Chemical features of flavonols affecting their genotoxicity. Potential implications in their use as therapeutical agents,” Chemico-Biological Interactions, vol. 124, no. 1, pp. 29–51, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. M. C. Sabini, L. N. Cariddi, F. M. Escobar et al., “Evaluation of the cytotoxicity, genotoxicity and apoptotic induction of an aqueous extract of Achyrocline satureioides (Lam.) DC,” Food and Chemical Toxicology, vol. 60, pp. 463–470, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. M. C. Sabini, F. M. Escobar, C. E. Tonn, S. M. Zanon, M. S. Contigiani, and L. I. Sabini, “Evaluation of antiviral activity of aqueous extracts from Achyrocline satureioides against Western equine encephalitis virus,” Natural Product Research, vol. 26, no. 5, pp. 405–415, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Mongini and C. Waldner, “Metodologías para la evaluación de las células inmunocompetentes,” in Inmunología e Inmunoquímica, R. A. Margni, Ed., pp. 730–734, Editorial Médica Panamericana, 1996. View at Google Scholar
  14. G. C. G. Militão, I. N. F. Dantas, C. Pessoa et al., “Induction of apoptosis by pterocarpans from Platymiscium floribundum in HL-60 human leukemia cells,” Life Sciences, vol. 78, no. 20, pp. 2409–2417, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Mosmann, “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,” Journal of Immunological Methods, vol. 65, no. 1-2, pp. 55–63, 1983. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Montaner, S. Navarro, M. Piqué et al., “Prodigiosin from the supernatant of Serratia marcescens induces apoptosis in haematopoietic cancer cell lines,” British Journal of Pharmacology, vol. 131, no. 3, pp. 585–593, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. D. J. Song, J. Y. Cho, M. Miller et al., “Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model,” Clinical Immunology, vol. 131, no. 1, pp. 157–169, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. Z. Amirghofran, M. Bahmani, A. Azadmehr, and K. Javidnia, “Immunomodulatory and apoptotic effects of Stachys obtusicrena on proliferative lymphocytes,” Medical Science Monitor, vol. 13, no. 6, pp. BR145–BR150, 2007. View at Google Scholar · View at Scopus
  19. G. Fiskesjö, “Allium test for screening chemicals; evaluation of cytological parameters,” in Plants for Environmental Studies, pp. 307–333, CRC, Lewis Publishers, New York, NY, USA, 1997. View at Google Scholar
  20. W. Schmid, “The micronucleus test,” Mutation Research, vol. 31, no. 1, pp. 9–15, 1975. View at Publisher · View at Google Scholar · View at Scopus
  21. L. E. Bröker, F. A. E. Kruyt, and G. Giaccone, “Cell death independent of caspases: a review,” Clinical Cancer Research, vol. 11, no. 9, pp. 3155–3162, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. E. D. Barioni, J. R. Santin, I. D. Machado et al., “Achyrocline satureioides (Lam.) D.C. hydroalcoholic extract inhibits neutrophil functions related to innate host defense,” Evidence-based Complementary and Alternative Medicine, vol. 2013, Article ID 787916, 12 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. M. C. Sabini, L. N. Cariddi, F. M. Escobar et al., “Evaluation of cytogenotoxic effects of cold aqueous extract from Achyrocline satureioides by Allium cepa L test,” Natural Product Communications, vol. 6, no. 7, pp. 995–998, 2011. View at Google Scholar · View at Scopus
  24. M. D. Bagatini, T. G. Vasconcelos, H. D. Laughinghouse IV, A. F. Martins, and S. B. Tedesco, “Biomonitoring hospital effluents by the Allium cepa L. test,” Bulletin of Environmental Contamination and Toxicology, vol. 82, no. 5, pp. 590–592, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. V. M. Vargas, R. R. Guidobono, and J. A. Henriques, “Genotoxicity of plant extracts,” Memorias do Instituto Oswaldo Cruz, vol. 86, pp. 67–70, 1991. View at Google Scholar · View at Scopus
  26. F. A. Resende, W. Vilegas, L. C. Dos Santos, and E. A. Varanda, “Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test,” Molecules, vol. 17, no. 5, pp. 5255–5268, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. C. F. Skibola and M. T. Smith, “Potential health impacts of excessive flavonoid intake,” Free Radical Biology and Medicine, vol. 29, no. 3-4, pp. 375–383, 2000. View at Publisher · View at Google Scholar · View at Scopus