Table 3: Genotoxic effects of hot aqueous extract of A. satureioides (As-HAE) on erythrocytes from bone marrow of mice.

TreatmentsAnimalsaPCE/NCE ± SD
(TI)b
24 h
MNPCEc() 
24 h

Negative control
(saline solution)
61.38 ± 0.355.75 ± 1.77
Hot aqueous extract of A. satureioides
(As-HAE)
(mg/kg bw)
 10060.23 ± 0.024.50 ± 1.54
 20060.22 ± 0.08 12.50 ± 1.31
 50060.30 ± 0.05 28.25 ± 2.35
Positive control
(cyclophosphamide)
6 1.20 ± 0.60 26.50 ± 8.02

Six mice were used per experimental group (3 males and 3 females). bToxicity index; cmicronucleated polychromatic erythrocytes. In all cases, 2000 polychromatic erythrocytes (PCE) per animal were analyzed; < 0.01, < 0.001 statistically significant difference from saline group (ANOVA Tukey test).