Research Article
Induction of Ankrd1 in Dilated Cardiomyopathy Correlates with the Heart Failure Progression
Table 4
Clinical characteristics of patients (
) with high radial strain (RS, above median) and low RS (below median).
| | | Radial strain | | Below median | Above median |
| | Age (years) | 48 ± 6.51 | 44 ± 3.3 | | Sex | | | | Female | 2 | 3 | | Male | 5 | 4 | | BMI (kg/m2) | 25.6 ± 2.0 | 27.03 ± 2.13 | | NYHA class | | | | III | 3 | 5 | | III-IV | 0 | 2 | | IV | 4 | 0 | | BNP (pg/mL | 1824 ± 461 | 525 ± 197 | | TnT (pg/mL) | 31.17 ± 6.1 | 157 ± 136.4 | | Adiponectin (μg/mL | 35 ± 5.4 | 8.5 ± 1.8 | | LVEF (%) | 21.29 ± 1.1 | 25.29 ± 3.34 | | LVESD (mm) | 61 ± 2.1 | 55.5 ± 2.1 | | LVEDD (mm) | 71.3 ± 2.1 | 65.6 ± 1.7 | | RAP (mmHg) | 12.33 ± 3.9 | 9.33 ± 1.28 | | PAP (mmHg) | 32.6 ± 4.7 | 25.3 ± 1.91 | | PCWP (mmHg) | 23.14 ± 3.8 | 18.17 ± 1.51 | | PVR (Wood units) | 2.5 ± 0.44 | 2.025 ± 0.55 | | E wave (m/s) | 1 ± 0.11 | 0.92 ± 0.06 | | A wave (m/s) | 0.398 ± 0.05 | 0.63 ± 0.095 | | E/A | 2.71 ± 0.36 | 1.86 ± 0.48 | | E wave (ms) | 118 ± 12 | 146 ± 15.42 | | 3C strain (% | −5.07 ± 0.96 | −8.75 ± 0.98 | | Radial strain (% | 7.39 ± 1.23 | 21.1 ± 1.95 | | Radial strain rate (s−1 | 0.88 ± 0.19 | 1.55 ± 0.13 | | ANKRD1 ( | −7.02 ± 1.1 | −10.26 ± 0.68 | | BCL-2 ()† | −16.36 ± 1.0 | −18.67 ± 0.22 | | BAX () | −14.60 ± 1.0 | −16.02 ± 0.17 | | BAX/BCL-2 ratio ( | 1.76 ± 0.27 | 2.65 ± 0.19 | | Active caspase-3 (ng/mg)† | 0.19 ± 0.06 | 0.45 ± 0.11 |
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< 0.05; † < 0.05 (Mann-Whitney test).
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