Research Article

Expression Signatures of Long Noncoding RNAs in Adolescent Idiopathic Scoliosis

Table 3

Genes biological processes.

Biological processesGene symbolGene nameEntrez gene IDFold changes

Nervous system developmentLTA “Phosphoinositide-3-kinase, catalytic, delta polypeptide”52932.1513674
TP53Tumor protein p5371572.0308032
MSH2“mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)”44362.0266845
BCL2BCL2-associated athanogene 395312.130905
TP53Tumor protein p5371572.0308032
NCLNuclear RNA export factor 1104822.00108
PAFAH1B1“Platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45 kDa)”50482.1079702
OLIG1Oligodendrocyte transcription factor 11164482.129439
PKD1Polycystic kidney disease 1 (autosomal dominant)2.18849
BTG2“BTG family, member 2”78322.7636645

Skeletal morphogenesis and developmentBCL2B-Cell CLL/lymphoma 25962.252202
IL6ST“Interleukin 6 signal transducer (gp130, oncostatin M receptor)”35722.2222419
MYCv-myc myelocytomatosis viral oncogene homolog (avian)46092.768515
TPP1Tripeptidyl peptidase I12002.0187664
AESAminoterminal enhancer of split1662.2728803
ALOX15Arachidonate 15-lipoxygenase2462.1062436

Muscle development and functionBCL2B-Cell CLL/lymphoma 25962.252202
FLI1Friend leukemia virus integration 123132.2254617
UTRNUtrophin74022.1682687
UTS2Urotensin 2109112.469184
HIF1A“Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)”30912.028285
TGFBR2“Transforming growth factor, beta receptor II (70/80 kDa)”70482.1115046
TTNTitin72732.7300012
LEF1Lymphoid enhancer-binding factor 1511763.1550286
HIF1A“Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)”30912.028285
FAM65B“Family with sequence similarity 65, member B”97502.247876
UTRNUtrophin74022.1682687

Notch signaling pathwayADAM17ADAM metallopeptidase domain 1768682.0420005
NOTCH2Notch 248532.1405845
CTBP1C-Terminal binding protein 114872.050679

MAPK signaling pathwayTAB2TGF-beta activated kinase 1/MAP3K7 binding protein 2231182.1040483
SOS1Son of sevenless homolog 1 (Drosophila)66542.0901704
DUSP16Dual specificity phosphatase 16808242.1876025
MAP3K1Mitogen-activated protein kinase kinase kinase 142142.343032
RPS6KA3“Ribosomal protein S6 kinase, 90 kDa, polypeptide 3”61972.0745454
CD14CD14 molecule9292.3363564
DUSP6Dual specificity phosphatase 618482.2230558
ARRB1“Arrestin, beta 1”4082.004528
TGFBR2“Transforming growth factor, beta receptor II (70/80 kDa)”70482.1115046
AKT3“v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)”100002.0013347
MYCv-myc myelocytomatosis viral oncogene homolog (avian)46092.768515
TP53Tumor protein p5371572.0308032
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 147902.0809784

Wnt signaling pathwayCAMK2GCalcium/calmodulin-dependent protein kinase II gamma8182.1046312
TCF7“Transcription factor 7 (T-cell specific, HMG-box)”69322.6018746
PPARDPeroxisome proliferator-activated receptor delta54672.1376982
TCF3“Transcription factor 7 (T-cell specific, HMG-box)”69322.8202255
CAMK2DCalcium/calmodulin-dependent protein kinase II delta8172.5258021
PLCB2“Phospholipase C, beta 2”53302.2920265
NFATC1“Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1”47722.0340881
MYCv-myc myelocytomatosis viral oncogene homolog (avian)46092.768515
TP53Tumor protein p5371572.0308032
LEF1Lymphoid enhancer-binding factor 1511763.1550286
CTBP1C-Terminal binding protein 114872.050679
PIAS4“Protein inhibitor of activated STAT, 4”515882.0654333
AESAminoterminal enhancer of split1662.2728803
INVSInversin271302.2433844
LRRFIP2Leucine rich repeat (in FLII) interacting protein 292092.1049194

Gene Ontology and Pathway analysis was performed for differentially expressed mRNAs. mRNAs involving musculoskeletal development are listed in their gene groups with associated Entrez Gene ID and fold changes per gene.