Expression Signatures of Long Noncoding RNAs in Adolescent Idiopathic Scoliosis
Table 5
Expressions of lncRNAs in different clinical features.
Features
ENST00000602322.1
ENST00000440778.1
ENST00000414894.1
TCONS_00028768
Menarche age (y)
≤11
7.29 ± 0.82
4.74 ± 0.88
3.04 ± 0.52
5.51 ± 1.08
>11
7.75 ± 1.20
5.09 ± 1.25
2.95 ± 0.75
5.62 ± 1.44
Height (cm)
≤160
7.49 ± 1.03
4.40 ± 0.71∗
2.98 ± 0.59
5.05 ± 0.99∗
>160
7.73 ± 1.17
5.34 ± 1.45∗
2.99 ± 0.78
5.95 ± 1.63∗
Onset of AIS (y)
≤12
6.73 ± 0.60∗∗
4.92 ± 1.09
3.09 ± 1.52
5.54 ± 1.19
>12
7.86 ± 1.29∗∗
5.01 ± 1.17
2.87 ± 1.17
5.63 ± 1.43
Numbers of curvesa
1
7.09 ± 0.74∗
4.95 ± 1.40
2.79 ± 0.66
5.81 ± 1.24
2
7.98 ± 1.19∗
4.98 ± 0.95
3.10 ± 0.66
5.46 ± 1.34
Cobb angle (°)
≤40
7.60 ± 1.36
5.11 ± 1.70
2.47 ± 0.63∗
5.59 ± 1.60
>40
7.58 ± 1.95
4.90 ± 0.72
3.38 ± 0.65∗
5.59 ± 1.15
Risser signb
≤3
7.51 ± 1.12
4.33 ± 0.81∗
2.93 ± 0.60
5.37 ± 0.97
>3
7.65 ± 1.07
5.21 ± 1.25∗
3.02 ± 0.72
5.76 ± 1.51
Relative lncRNAs levels were normalized to GAPDH (Ct = CtlncRNA − CtGAPDH). Results are presented as mean ± standard deviation. < 0.05, < 0.01. aCurves were counted and classified into single, double, and triple curves according to the apex number. bRisser sign refers to the amount of calcification of the human pelvis as a measure of maturity. On a scale of 5, it gives a measurement of ossification progression; the grade of 5 means that skeletal maturity is reached.
