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BioMed Research International
Volume 2015 (2015), Article ID 279192, 8 pages
Research Article

Short Duration Combined Mild Hypothermia Improves Resuscitation Outcomes in a Porcine Model of Prolonged Cardiac Arrest

1Emergency Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
2Institute of Cardiopulmonary Cerebral Resuscitation, Sun Yat-sen University, Guangzhou 510120, China
3Emergency Department, Affiliated Dongguan Hospital, Medical College of Jinan University, Dongguan 523900, China
4Biomedical Engineering Department, Guangzhou Medical University, Guangzhou 511436, China
5School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China

Received 22 May 2015; Revised 24 August 2015; Accepted 21 September 2015

Academic Editor: Clifton W. Callaway

Copyright © 2015 Tao Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. In this study, our aim was to investigate the effects of combined hypothermia with short duration maintenance on the resuscitation outcomes in a porcine model of ventricular fibrillation (VF). Methods. Fourteen porcine models were electrically induced with VF and untreated for 11 mins. All animals were successfully resuscitated manually and then randomized into two groups: combined mild hypothermia (CH group) and normothermia group (NT group). A combined hypothermia of ice cold saline infusion and surface cooling was implemented in the animals of the CH group and maintained for 4 hours. The survival outcomes and neurological function were evaluated every 24 hours until a maximum of 96 hours. Neuron apoptosis in hippocampus was analyzed. Results. There were no significant differences in baseline physiologies and primary resuscitation outcomes between both groups. Obvious improvements of cardiac output were observed in the CH group at 120, 180, and 240 mins following resuscitation. The animals demonstrated better survival at 96 hours in the CH group when compared to the NT group. In comparison with the NT group, favorable neurological functions were observed in the CH group. Conclusion. Short duration combined cooling initiated after resuscitation improves survival and neurological outcomes in a porcine model of prolonged VF.