Cinnabar Induces Renal Inflammation and Fibrogenesis in Rats

Figure 1

Cinnabar caused tubulointerstitial damage in rats. Renal sections were stained with hematoxylin and eosin (HE). (a) The control group, 8 weeks. ((b)–(d)) The cinnabar group, 8 weeks. (e) The control group, 12 weeks. ((f)–(h)) The cinnabar group, 12 weeks. (a) and (e) show the normal histology of the kidney. (b) and (f) show vacuolization of tubular cells (indicated by arrows), (c) and (g) show protein casts in tubules (indicated by arrows), and (d) and (h) show infiltration of inflammatory cells in cinnabar-treated rats. Scale bar = 20 μm.