BioMed Research International / 2015 / Article / Tab 1

Review Article

Experimentally Induced Mammalian Models of Glaucoma

Table 1

Experimentally induced in vivo mammalian glaucoma models.

In vivo glaucoma models Species Main papers Main outcomes measured Cost Limitation


Laser photocoagulation of the perilimbal region
Monkey Gaasterland and Kupfer (1974) [11] IOP, cupping, HR, HI, OF Expensive (laser equipment)Ocular inflammation
Irreversible mydriasis
Technical difficulties
Mouse Aihara et al. (2003) [19]
Mabuchi et al. (2003) [20]
IOP
IOP, HR
Ocular inflammation
Variability of IOP
Technical difficulties
Rat Levkovitch-Verbin et al. (2002) [42] IOP, HR, HI Hyphema, corneal opacity
Ocular inflammation

RBC injections into the anterior chamber Monkey Quigley and Addicks (1980) [12, 47] IOP, HR, HI, OF Low visibility of optic discs by accumulation of RBC or microbeads  
Microbead injections into the anterior chamberRat
Mouse
Weber and Zelenak (2001) [48]
Pang et al. (2005) [40]  
Sappington et al. (2010) [49]
IOP, HR, HI
IOP
IOP, HR, HI
Not expensive
Hyaluronic acid injection into the anterior chamberRat Moreno et al. (2005) [51] IOP, HR, HI, ERG

Episcleral vein obstruction Rat Shareef et al. (1995) [15] IOP Not expensive Scleral thermal burns (RGC death patterns may be different from those of other glaucoma models)
Mouse Ruiz-Ederra and Verkman (2006) [54] IOP, HR, OF

Episcleral vein saline injection Rat  
Mouse
Morrison et al. (1997) [14]  
Kipfer-Kauer et al. (2010) [59]
IOP, HR, HI
IOP, HR
Not expensive Technical difficulties

IOP: IOP measurement, cupping: assessment of optic disc cupping, HR: histological assessment of retinal nerve fibers and optic discs, HI: histological assessment of the iridocorneal angles, OF: outflow facility, ERG: electroretinography.

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