The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population
Table 1
Body dimensions, distribution of body fat storage, and metabolic markers profile according to BMI.
Classification
Normal range
Preobese
Obese
BMI (kg/m2)
[22.4 (18.5–24.9)]
[27.4 (25.1–29.6)]
[34.1 (30.3–45.4)]
153
144
78
Measurements
Height (cm)&
164.7 ± 0.08
163.5 ± 0.09
163.4 ± 0.09
Body weight (kg)*
61.2 ± 8.6
73.5 ± 9.3
91.4 ± 13.9
Total body fat mass (kg)*
14.4 ± 5.7
22.9 ± 5.2
36.2 ± 8.9
Body fat ratio*
5.34 ± 2.18
8.56 ± 2.05
13.61 ± 3.38
Waist circumference (cm)*
78.3 ± 8.2
91.6 ± 8.1
106.5 ± 10.8
Hip circumference (cm)*
95.7 ± 6.1
102.6 ± 5.2
116.9 ± 10.2
WHR+
0.85 ± 0.12
0.86 ± 0.12
0.90 ± 0.10
WthR*
0.47 ± 0.04
0.56 ± 0.04
0.64 ± 0.06
Total adipose area (cm2)*
493 ± 105
672 ± 119
896 ± 183
Conicity index*
1.18 ± 0.10
1.25 ± 0.08
1.29 ± 0.09
Abdominal volume index (L)*
12.65 ± 2.54
17.04 ± 2.90
22.72 ± 4.55
Glucose (mg/dL)*
87 ± 11
96 ± 12
98 ± 13
Insulin (μIU/mL)*
14.1 ± 24.3
16.8 ± 13.9
25.1 ± 29.9
HOMA-IR*
2.97 ± 5.05
4.00 ± 3.41
5.89 ± 7.03
Triglycerides (mg/dL)+
115 ± 64
167 ± 103
153 ± 79
Total cholesterol (mg/dL)+
172 ± 37
192 ± 41
192 ± 31
HDLc (mg/dL)&
40.7 ± 16.0
37.2 ± 13.1
37.9 ± 14.2
LDLc (mg/dL)*
105 ± 35
113 ± 36
117 ± 26
VLDLc (mg/dL)+
23.1 ± 12.9
33.0 ± 20.5
30.4 ± 15.9
Apolipoprotein A-1 (mg/dL)&
118 ± 29
112 ± 22
117 ± 27
Apolipoprotein B (mg/dL)+
98 ± 28
124 ± 34
115 ± 27
Total sAdiponectin (ng/mL)+
7570 ± 340
3665 ± 293
4489 ± 351
sResistin (ng/mL)+
8.4 ± 2.5
9.7 ± 3.2
10.5 ± 3.7
sLeptin (ng/mL)*
17.6 ± 14.6
23.8 ± 15.4
57.5 ± 30.7
Abdominal obesity (%)
3.2
32.9
74.7
Dyslipidemia (%)
16.8
32.9
31.3
Data are means ± SD. One-way ANOVA test and Tukey post hoc test of normal range versus preobesity and obesity, and preobesity versus obesity, *all measurements were different ( < 0.05), +exception where only normal range versus obesity was different. &No signifies differences were found. BMI: body mass index; WHR: waist-hip ratio; WthR: waist height ratio; HOMA-IR: homeostasis model assessment-insulin resistance; HDLc, LDLc, and VLDLc: high, low, and very low density lipoprotein cholesterol, respectively.
