The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population
Table 3
Distribution of Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 polymorphisms in Mexican-Mestizo population.
Study group
Genotype (%)
Phenotype (%)
Allele (%)
PPARGC1A Gly482Ser rs8192678
Gly/Gly (Ser−)
Gly/Ser
Ser/Ser (Gly−)
Gly+
Ser+
Gly
Ser
Normal range
77 (50)
60 (39)
16 (11)
137 (89)
76 (50)
214 (70)
92 (30)
Preobese
74 (51)
54 (38)
16 (11)
128 (89)
70 (49)
202 (70)
86 (30)
Obese
38 (49)
31 (40)
9 (11)
69 (89)
40 (51)
107 (70)
49 (30)
1NS
2NS
2NS
5NS
Without obesity
151 (51)
114 (38)
32 (11)
265 (89)
146 (49)
416 (70)
178 (30)
3NS
4NS
4NS
6NS
PPARG2 Pro12Ala rs1801282
Pro/Pro (Ala−)
Pro/Ala
Ala/Ala (Pro−)
Pro+
Ala+
Pro
Ala
Normal range
117 (76)
34 (23)
2 (1)
151 (99)
36 (24)
268 (87)
38 (13)
Preobese
117 (81)
27 (19)
0 (0)
144 (100)
27 (19)
261 (90)
27 (10)
Obese
61 (78)
13 (17)
4 (5)
74 (95)
17 (22)
135 (87)
21 (13)
10.047
20.014
2NS
5NS
Without obesity
234 (78)
61 (21)
2 (1)
295 (99)
63 (22)
529 (89)
65 (11)
30.017
40.019
4NS
6NS
; NS: not significant; categorical variables were analyzed using χ2 or Fisher exact test, accordingly. Comparisons: 1normal range (BMI 18.5–24.9 kg/m2), preobese (BMI 25–29.9 kg/m2), and obese (BMI ≥ 30 kg/m2) by genotype; 2normal range, preobese, and obese by phenotype; 3obese and without obesity (BMI: 18.5–29.9 kg/m2) by genotype; 4obese and without obesity by phenotype; 5normal range, preobese, and obese by allele; 6normal range and without obesity by allele.
